Pretreatment of human myocardium with adenosine
نویسندگان
چکیده
منابع مشابه
Pretreatment of human myocardium with adenosine.
OBJECTIVES While the role of adenosine pretreatment in animals has been well established, the role in humans has been controversial. We performed this prospective, randomized study to find out the usefulness of adenosine pretreatment in humans. PATIENTS AND METHODS Twenty patients undergoing coronary artery bypass surgery for severe triple vessel disease and left ventricular dysfunction (ejec...
متن کاملPretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty.
OBJECTIVES We tested the hypothesis that enalaprilat induces preconditioning (PC)-mimetic actions in patients with stable coronary artery disease. BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors increase the bioavailability of bradykinin, which induces cardiac PC. METHODS Twenty-two patients undergoing coronary angioplasty were randomized to an intracoronary infusion of enalaprila...
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There is increasing evidence for interactions among adenosine receptor subtypes in the brain and heart. The purpose of this study was to determine whether the adenosine A(2a) receptor modulates the infarct size-reducing effect of preischemic administration of adenosine receptor agonists in intact rat myocardium. Adult male rats were submitted to in vivo regional myocardial ischemia (25 min) and...
متن کاملAdenosine-mediated cardioprotection in the aging myocardium.
With aging, it appears the heart's ability to withstand injury declines markedly. Unfortunately, the incidence of ischemic disorders increases dramatically with age. Though the genesis of the ischemia-intolerant phenotype is incompletely understood (and likely multi-factorial), it may involve changes in intrinsic cardioprotective responses. In this respect we and others have interrogated the ro...
متن کاملIsoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels.
BACKGROUND Volatile anesthetics produce differing degrees of myocardial protection in animal models of ischemia. The purpose of the current investigation was to determine the influence of isoflurane and halothane on myocardial protection in a human model of simulated ischemia and the role of adenosine A1 receptors and adenosine triphosphate-sensitive potassium (KATP) channels in the anesthetic ...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2001
ISSN: 1010-7940
DOI: 10.1016/s1010-7940(00)00605-9